Drusen typically deposits between which layers of the retina?

Drusen are formed as deposits of extracellular material that typically accumulate between the retinal pigment epithelium and Bruch's membrane. This specific location is significant because it relates to the early changes in age-related macular degeneration (AMD), a leading cause of vision loss. When drusen accumulate in this area, they can disrupt the functionality of the retinal pigment epithelial cells, which play a crucial role in supporting photoreceptors and maintaining the overall health of the retina.

Understanding the interaction between the retinal pigment epithelium and Bruch's membrane is critical for recognizing how drusen can contribute to visual impairment. Changes in this interface can affect nutrient transport, waste removal, and overall retinal health, which denounces their significance in clinical optometry and patient management.