What is the net overall moles of ATP produced by the electron transport chain (i.e. not including glycolysis)?

The net overall moles of ATP produced by the electron transport chain (ETC) typically yields about 34 moles of ATP when considering the complete oxidation of one molecule of glucose, excluding contributions from glycolysis and the citric acid cycle.

During cellular respiration, the electron transport chain utilizes the high-energy electrons delivered by NADH and FADH2 to generate a proton gradient across the inner mitochondrial membrane. As protons flow back into the mitochondrial matrix through ATP synthase, ATP is produced via oxidative phosphorylation. Each molecule of NADH contributes to the production of approximately 2.5 ATP, and each molecule of FADH2 contributes to about 1.5 ATP due to the different points at which they enter the electron transport chain.

In summary, when accounting for the contributions from NADH and FADH2 generated in previous stages of respiration, the total production from the electron transport chain alone amounts to 34 moles of ATP, reflecting the efficiency of this pathway in energy production.