What total cumulative dosage of chloroquine is commonly associated with retinal toxicity?

The total cumulative dosage of chloroquine that is commonly associated with retinal toxicity is around 300 grams. Chloroquine is an antimalarial medication that, while effective for treating malaria and certain autoimmune conditions, can lead to potential retinal damage if used over long periods or at high doses.

The threshold for concern typically arises when the total cumulative dosage approaches 300 grams. Beyond this point, patients are at an increased risk of developing chloroquine-induced retinopathy, which can manifest as a range of visual disturbances and damage to the retinal pigment epithelium.

Understanding this threshold is crucial for clinicians to monitor patients who are on long-term chloroquine therapy and to adjust their treatment plans as necessary to minimize the risk of retinal toxicity.